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LoVe score estimated ventilation beyond 48 hours, but needs prospective testing

Journal of the Intensive Care Society (PubMed)Aug 28, 2026

AI-summarized from the linked source. Educational brief, not medical advice.

Brief summary

A retrospectively developed and externally validated bedside score showed modest-to-good discrimination for predicting invasive ventilation beyond 48 hours, but prospective clinical validation is still needed.

What NurseJet pulled from the source

Researchers developed ventilator-inclusive and ventilator-agnostic LoVe indices using AmsterdamUMCdb and tested them in MIMIC-IV. External-validation AUROCs ranged from 0.65 to 0.71 depending on cohort and version, while development/internal-validation AUROCs ranged from 0.72 to 0.82. The outcome combined ventilation beyond 48 hours with death within 48 hours.

Why this matters for nurses

Expected ventilation duration can influence early equipment, prevention, communication, and resource planning. ICU nurses should understand what a prediction tool can add while preventing a score from replacing assessment, protocol criteria, or multidisciplinary judgment.

Bedside takeaway

Treat the LoVe score as an unproven decision-support input, not as a reason to change ventilator settings or override clinical judgment.

Key takeaways

The score uses routinely available peri-intubation data to estimate ventilation beyond 48 hours.
External-validation AUROCs ranged from 0.65 to 0.71, lower than several development and internal-validation estimates.
The authors reported net benefit in decision-curve analyses, but no prospective impact on patient outcomes was tested.
Ventilator settings in the model are predictors, not causal targets that should be changed to alter the score.

Practice implications

If the score is locally approved, enter peri-intubation data accurately and interpret the output alongside trajectory, diagnosis, frailty, ventilator response, and team assessment. Do not change ventilator settings to manipulate a prediction or use the score alone for treatment decisions.

Limitations & cautions

The study was retrospective, discrimination was modest in external validation, and the model omitted potentially important factors such as diagnosis and frailty. Its clinical value and effect on patient outcomes have not been established prospectively.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations

Exact source links

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Journal of the Intensive Care Society (PubMed)

Journal of the Intensive Care Society (PubMed). The LoVe score: Development and validation of a bedside clinical index to identify patients at risk for prolonged invasive mechanical ventilation.

Open original source

https://pubmed.ncbi.nlm.nih.gov/42668746/

Professional education only

This summary does not replace clinical judgment, facility policy, provider orders, or official guidelines. Verify practice changes against the original source and local protocol.

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A smaller creatinine rise may receive less attention even when it meets the study's laboratory definition of acute kidney injury, which can affect how renal risk is communicated across the inpatient team.

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Trend ordered renal-function results and communicate clinically important changes through local escalation and documentation workflows.

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Trend ordered renal-function results and communicate clinically important changes through the care team according to local escalation and documentation workflows.

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Abstract-only summary. This was a retrospective, single-center study of 161 hospitalizations; urine-output criteria and reliable preadmission creatinine values were unavailable, and the reference creatinine method may affect case classification.
AI-summarized from the linked source. Review the original article before applying to practice.

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Renal failure (PubMed). Underdocumentation of laboratory-defined acute kidney injury in internal medicine wards: a retrospective cohort study.

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The trial does not support empiric intravenous proton-pump inhibition for persistent vomiting in pediatric acute gastroenteritis after ondansetron.

Bedside takeaway

Clarify the indication for empiric acid suppression and keep hydration and oral-tolerance assessment central to care.

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Prioritize the ordered hydration and oral-tolerance plan, document ongoing emesis, and clarify the indication before administering empiric acid suppression.

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AI-summarized from the linked source. Review the original article before applying to practice.

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Bedside takeaway

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Nursing implications

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Abstract-only summary. The trial included 630 participants, 78.1% were men, the primary confidence interval included benefit and no benefit, and individual secondary outcomes were not the primary endpoint.
AI-summarized from the linked source. Review the original article before applying to practice.

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European heart journal (PubMed). Targeted vitamin D supplementation and major adverse cardiovascular events after myocardial infarction: the TARGET-D trial.

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AI-summarized from the linked source. Review the original article before applying to practice.

Key takeaways

Practice implications

Limitations & cautions

Exact source links

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