Systematic ReviewResearchPatient Education

Venepuncture probably reduced pain and repeat punctures versus heel lance in term newborns without sweet solutions

The Cochrane database of systematic reviews (PubMed)Jul 17, 2026

AI-summarized from the linked source. Educational brief, not medical advice.

Brief summary

An updated Cochrane review of eight randomized or quasi-randomized studies involving 826 term neonates found moderate-certainty evidence that venepuncture probably reduced procedural pain and repeat punctures versus heel lance when no sweet-tasting analgesic solution was used.

What NurseJet pulled from the source

This Cochrane review update compared venepuncture with heel lance for blood sampling in term neonates. Eight randomized or quasi-randomized studies with 826 infants were included, and overall risk of bias was judged high. Without a sweet-tasting solution, venepuncture probably reduced pain and the need for more than one puncture, based on moderate-certainty evidence. With a sweet-tasting solution, venepuncture may reduce pain, but evidence was low certainty, and the effect on repeat punctures was very uncertain. The findings depend on the analgesia context and do not replace neonatal sampling competency or pain-management protocols.

Why this matters for nurses

Pediatric and newborn nurses perform or support frequent blood sampling and assess procedural pain. This review distinguishes the evidence by sampling method and whether a sweet-tasting analgesic solution is used.

Bedside takeaway

Venepuncture probably reduced pain and repeat punctures without sweet solutions, but the evidence changes when analgesic solutions are used.

How This Applies in Practice

Use this when: Preparing to obtain a provider-ordered blood sample from a term neonate.

On your shift

Confirm the approved collection method and pain-management plan and ensure the clinician performing the procedure has the required competency.
Assess procedural pain, record the number of punctures, and escalate repeated unsuccessful attempts through the unit pathway.

Keep in mind: Do not choose a sampling or analgesia method from this review alone. Follow the neonatal protocol, facility policy, and patient-specific provider orders.

Explain this for my unit

Key takeaways

The updated Cochrane review included eight studies and 826 term neonates.
Without a sweet-tasting solution, venepuncture probably reduced pain and repeat punctures versus heel lance.
With a sweet-tasting solution, pain evidence was low certainty and repeat-puncture evidence was very uncertain.
All eight studies had an overall high risk of bias, particularly around blinding and allocation concealment.

Practice implications

Before collecting a term newborn's sample, confirm the ordered test, approved collection method, staff competency, and neonatal pain-management plan. Use a validated pain assessment and document the number of punctures; escalate repeated unsuccessful attempts according to the unit pathway.

Limitations & cautions

The eight included studies had an overall high risk of bias and substantial pain-score heterogeneity. Evidence with sweet-tasting solutions was low or very low certainty, and the repeat-puncture estimate in that context was based on only 110 infants with a very wide confidence interval.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations

Exact source links

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The Cochrane database of systematic reviews (PubMed)

The Cochrane database of systematic reviews (PubMed). Venepuncture versus heel lance for blood sampling in term neonates.

Open original source

https://pubmed.ncbi.nlm.nih.gov/42466545/

Professional education only

This summary does not replace clinical judgment, facility policy, provider orders, or official guidelines. Verify practice changes against the original source and local protocol.

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European journal of psychotraumatology (PubMed)Jul 21, 2026Research ArticlePractice applicable

In a randomized trial of 55 participants age 12 to 25 with co-occurring post-traumatic stress and substance use disorders, integrated exposure-based COPE-A produced greater and faster improvement in PTSD outcomes than person-centered supportive therapy.

Psych PedsAI summaryReview source

Research ArticleResearchPatient EducationPractice applicableAI summary · original source linked below

At four months, COPE-A produced a 9.82-point greater reduction in PTSD symptom severity and lower odds of meeting PTSD diagnostic criteria than the comparison therapy; improvements were maintained through 12 months. Both groups reduced substance use and disorder severity over time, with no significant between-group difference. Participants reported greater satisfaction with COPE-A, and no study-related adverse events were reported.

Key takeaways

The trial randomized 55 adolescents and young adults age 12 to 25 to COPE-A or person-centered supportive therapy.
COPE-A produced a greater reduction in PTSD symptoms by the four-month primary endpoint.
Substance-use outcomes improved over time in both groups without a significant between-group difference.
The small single-region trial reported no study-related adverse events but cannot establish safety or effectiveness across all youth settings.

Why this matters on shift

Mental-health nurses often care for young people whose trauma symptoms and substance use interact, complicating engagement and treatment planning. The trial supports coordinated treatment rather than requiring PTSD work to wait for substance-use remission, while leaving exposure therapy to appropriately trained clinicians.

Bedside takeaway

Integrated therapy accelerated PTSD improvement, while substance-use outcomes were similar and treatment still requires trained clinical oversight.

Nursing implications

Assess and document trauma symptoms, substance use, acute risk, engagement barriers, and treatment goals without framing one condition as a reason to ignore the other. Support attendance and coping plans, monitor response and safety, and communicate changes to the clinician delivering the integrated therapy.

Limitations & cautions

The trial enrolled 55 participants in Sydney, most of whom were female, and compared two active psychotherapies. The small sample limits subgroup and uncommon-harm assessment, substance-use outcomes did not differ between groups, and results may not generalize to other ages, settings, treatment models, or levels of acuity.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

European journal of psychotraumatology (PubMed). Integrated exposure-based therapy for co-occurring post-traumatic stress and substance use among young people: a randomized controlled trial.

Explain this for my unit

Open original sourceFull brief

AI-summarized from the linked source. Review the original article before applying to practice.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses (PubMed)Jul 15, 2026Research ArticlePractice applicable

In 183 paired COMFORTneo assessments, overall agreement was excellent, but interrater reliability increased from 0.41 at 24 to 26 weeks' gestation to 0.92 at 36 weeks or later, indicating less consistent scoring in extremely preterm infants.

Peds ICUAI summaryReview source

Research ArticleResearchQuality ImprovementPractice applicableAI summary · original source linked below

Twenty-one NICU nurses and 12 nursing students completed paired assessments across five gestational-age groups. Overall intraclass correlation was 0.85, but agreement was much lower in infants born at 24 to 26 weeks. Body movement had the lowest item-level agreement, while respiratory response had the highest. Students had slightly higher agreement than experienced nurses, and item characteristics explained more variation than rater differences.

Key takeaways

The study analyzed 183 paired assessments by 21 NICU nurses and 12 nursing students.
Overall COMFORTneo interrater reliability was excellent at 0.85.
Reliability ranged from 0.41 at 24 to 26 weeks' gestation to 0.92 at 36 weeks or later.
Lower agreement in extremely preterm infants and variation by scale item support structured calibration and cautious interpretation.

Why this matters on shift

Extremely preterm infants cannot self-report pain and may display subtle or atypical behavioral cues. NICU nurses depend on consistent assessment to communicate distress, evaluate trends, and support treatment decisions, making gestational age and team calibration clinically important.

Bedside takeaway

COMFORTneo agreement was lower in extremely preterm infants, so item-level observation, team calibration, and reassessment remain important.

Nursing implications

Score the approved neonatal pain tool at the specified times, document contextual factors and item-level observations, and compare trends rather than relying on one number. When scores and the clinical picture conflict, repeat assessment with an experienced colleague and escalate through the neonatal pain pathway.

Limitations & cautions

This was a reliability study rather than a test of diagnostic accuracy, treatment response, or patient outcomes. The sample involved 183 paired assessments from one clinical context, subgroup sizes were unequal, and there is no objective pain reference standard, particularly for extremely preterm infants.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

Advances in neonatal care : official journal of the National Association of Neonatal Nurses (PubMed). Evaluating the Interrater Reliability of the COMFORTneo Scale in Infants: Influence of Gestational Age and Rater Experience.

Explain this for my unit

Open original sourceFull brief

AI-summarized from the linked source. Review the original article before applying to practice.

European journal of pediatrics (PubMed)Jul 21, 2026Research ArticlePractice applicable

In a randomized crossover trial of intra-articular injections for juvenile idiopathic arthritis, intranasal dexmedetomidine and inhaled nitrous oxide produced similarly mild immediate patient-reported pain, while recalled pain was lower with nitrous oxide and 69% preferred it for future sedation.

Peds Med-SurgAI summaryReview source

Research ArticleResearchMedication SafetyPatient EducationPractice applicableAI summary · original source linked below

Sixty-eight patients age 1 to 18 years received a randomized first sedation option, and 43 received both medications at separate visits. Immediate postprocedure pain did not differ between intranasal dexmedetomidine and nitrous oxide. At follow-up, patients recalled less pain after nitrous oxide, and 69% said they would prefer nitrous oxide in the future. Pain was also lower at the second visit regardless of medication, suggesting that familiarity with the procedure may have influenced experience.

Key takeaways

The trial included 68 children and adolescents, with 43 receiving both sedation options at separate visits.
Immediate patient-reported pain was mild and did not differ significantly between dexmedetomidine and nitrous oxide.
Recalled pain favored nitrous oxide, and 69% of participants preferred it for future sedation.
Pain was lower at the second visit regardless of the sedative, so visit order and familiarity may have affected experience.

Why this matters on shift

Pediatric nurses prepare children for repeated procedures, monitor sedation, assess pain with developmentally appropriate tools, and bring patient and caregiver preferences into planning. The crossover findings show that immediate pain scores and the child's later experience can point in different directions.

Bedside takeaway

Both options produced mild immediate pain, while nitrous oxide was preferred later, making monitoring, preparation, and patient preference all relevant.

Nursing implications

Use the local sedation pathway for preprocedure screening, medication administration, physiologic monitoring, recovery, and discharge readiness. Assess both immediate pain and the child's later recollection when available, document preferences, and use age-appropriate preparation to reduce uncertainty before repeat injections.

Limitations & cautions

Only 43 participants completed both treatment visits, and the second visit was less painful regardless of medication, introducing a likely period or familiarity effect. The abstract does not provide detailed adverse-event results, and findings from a pediatric rheumatology clinic may not generalize to other procedures, settings, doses, or patient groups.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

European journal of pediatrics (PubMed). Intranasal dexmedetomidine vs. nitrous oxide for procedural sedation in juvenile idiopathic arthritis (INDEXJIA): a randomized crossover clinical trial.

Explain this for my unit

Open original sourceFull brief

AI-summarized from the linked source. Review the original article before applying to practice.

How This Applies in Practice

Key takeaways

Practice implications

Limitations & cautions

Exact source links

More updates for this clinical area

Integrated exposure therapy reduced PTSD symptoms faster in young people with substance use

COMFORTneo pain ratings were less consistent in extremely preterm infants

Children reported similar immediate pain with two JIA sedation options but preferred nitrous oxide for future procedures