Systematic ReviewResearchWorkflow

Stroke nurses cut door-to-needle time and were linked to lower stroke mortality in a meta-analysis

Journal of Stroke and Cerebrovascular Diseases (PubMed)Feb 1, 2025

AI-summarized from the linked source. Educational brief, not medical advice.

Brief summary

A systematic review and meta-analysis found that adding a dedicated stroke nurse to acute stroke teams was associated with faster door-to-needle time and lower three-month mortality.

What NurseJet pulled from the source

Pooling eight studies, stroke nurse involvement was associated with a shorter door-to-needle time (about 20 minutes faster), lower three-month mortality (OR 0.56), better functional outcomes (OR 1.33), and higher thrombolysis rates (OR 1.52). Length of hospital stay was comparable with or without a stroke nurse.

Why this matters for nurses

In acute ischemic stroke, time is brain, and door-to-needle time depends heavily on coordinated nursing at the front of the pathway. This may matter for nurses because it quantifies how a dedicated stroke-nurse role is associated with faster thrombolysis and lower mortality.

Bedside takeaway

Worth knowing that adding a dedicated stroke nurse was associated with roughly 20 minutes faster door-to-needle time, higher thrombolysis rates, and lower three-month mortality.

Key takeaways

Across eight studies, stroke nurse involvement was linked to a roughly 20-minute shorter door-to-needle time.
Three-month mortality was lower (OR 0.56) and good functional outcomes more likely (OR 1.33).
Intravenous thrombolysis rates increased (OR 1.52).
Length of hospital stay was similar with or without a stroke nurse.

Practice implications

Support streamlined stroke-nurse workflows that compress door-to-needle steps such as rapid assessment, imaging coordination, and thrombolysis setup, use BE-FAST recognition with prompt pathway activation, and advocate for a defined stroke-nurse role where one does not exist.

Limitations & cautions

Only eight studies were pooled, with variation in stroke systems and possible bias. These are associations from observational and trial data, not proof that the nurse role alone causes the outcomes.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations

Exact source links

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Journal of Stroke and Cerebrovascular Diseases (PubMed)

Journal of Stroke and Cerebrovascular Diseases (PubMed). Effects of stroke nurse-led acute stroke management on treatment time benchmarks, intravenous thrombolysis rates, and patient outcomes: A systematic review and meta-analysis.

Open original source

https://pubmed.ncbi.nlm.nih.gov/39740694/

Professional education only

This summary does not replace clinical judgment, facility policy, provider orders, or official guidelines. Verify practice changes against the original source and local protocol.

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Pediatric emergency care (PubMed)Sep 7, 2026Research Article

A double-blind randomized trial found no reduction in vomiting or faster oral tolerance with intravenous pantoprazole versus placebo in children with acute gastroenteritis and persistent vomiting after ondansetron.

Peds EmergencyAI summaryReview source

Research ArticleResearchMedication SafetyAI summary · original source linked below

The trial randomized 100 children. Vomiting episodes and oral tolerance at 6 and 12 hours did not differ significantly, while median hospital stay was 2 days with pantoprazole and 1 day with placebo.

Key takeaways

The median participant age was 14 months, and 67% of participants were male.
Oral tolerance at 12 hours was 86% in both groups.
The longer stay associated with pantoprazole requires cautious interpretation because this was a single-center trial.

Why this matters on shift

The trial does not support empiric intravenous proton-pump inhibition for persistent vomiting in pediatric acute gastroenteritis after ondansetron.

Bedside takeaway

Clarify the indication for empiric acid suppression and keep hydration and oral-tolerance assessment central to care.

Nursing implications

Prioritize the ordered hydration and oral-tolerance plan, document ongoing emesis, and clarify the indication before administering empiric acid suppression.

Limitations & cautions

Abstract-only summary. This was a single-center study of 100 children in Tehran, and the abstract does not describe adverse events or explain why hospitalization was longer in the pantoprazole group.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

Pediatric emergency care (PubMed). Effect of Intravenous Pantoprazole on Clinical Outcomes in Pediatric Acute Gastroenteritis: A Placebo-Controlled RCT.

Open original sourceFull brief

AI-summarized from the linked source. Review the original article before applying to practice.

Journal of neurosurgical anesthesiology (PubMed)Sep 4, 2026Research Article

A five-center randomized trial found similar rescue-opioid use and moderate-to-severe PACU pain with dexmedetomidine-based opioid-sparing analgesia and fentanyl-based analgesia during elective craniotomy for brain tumors.

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Research ArticleResearchMedication SafetyAI summary · original source linked below

The trial randomized 500 adults. Moderate-to-severe PACU pain occurred in 145 of 242 assessed participants in the fentanyl group and 138 of 233 in the dexmedetomidine group, with no significant difference.

Key takeaways

Intraoperative rescue fentanyl use did not differ significantly between groups.
Hypotension was more common with dexmedetomidine, while postoperative shivering was less common.
Other in-hospital outcomes were similar between the two regimens.

Why this matters on shift

An opioid-sparing label did not translate into better early pain control in this trial, and the differing hypotension and shivering profiles remain relevant during perioperative handoff and recovery monitoring.

Bedside takeaway

Monitor pain, hemodynamics, sedation, and shivering in relation to the analgesic regimen and local protocol.

Nursing implications

During PACU and postoperative handoff, monitor pain, hemodynamics, sedation, and shivering according to the administered regimen and local protocol.

Limitations & cautions

Abstract-only summary. The trial involved elective tumor craniotomy at five Indian centers, both groups also received locoregional analgesia, and the abstract does not provide longer-term outcome results in detail.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

Journal of neurosurgical anesthesiology (PubMed). Opioid-Sparing Versus Opioid-Based Analgesia for Craniotomy: A Multicenter Randomized Controlled Trial.

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AI-summarized from the linked source. Review the original article before applying to practice.

BMC geriatrics (PubMed)Sep 5, 2026Research Article

A multicountry emergency-department analysis found that older patients' presenting complaints did not by themselves reflect underlying severity or disposition risk.

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Research ArticleResearchNew Grad FriendlyAI summary · original source linked below

The analysis included 2,794 adults aged 65 or older with one non-traumatic chief complaint across 36 emergency departments in nine European countries. Shortness of breath was associated with threefold admission odds and 2.2-fold in-hospital mortality odds.

Key takeaways

Shortness of breath, abdominal pain, chest pain, weakness or fatigue, and extremity symptoms accounted for 59% of presentations.
Age 85 or older, geriatric risk factors, polypharmacy, and shortness of breath were associated with admission.
The authors called for structured evaluation, staff training, and geriatric-specific care pathways.

Why this matters on shift

A seemingly routine complaint can coexist with frailty, polypharmacy, cognitive impairment, or other risks that change emergency assessment and disposition planning.

Bedside takeaway

Pair the presenting complaint with structured geriatric, medication, cognitive, functional, and physiologic assessment.

Nursing implications

Pair the chief complaint with structured geriatric, medication, cognitive, functional, and physiologic assessment using local emergency protocols.

Limitations & cautions

Abstract-only summary. This was a secondary observational analysis of seven-day samples collected during the 2020 COVID-19 pandemic; associations do not prove causation and may not generalize to all emergency settings.
AI-summarized from the linked source. Review the original article before applying to practice.

Citations · exact source links

BMC geriatrics (PubMed). Non-traumatic chief complaints in older patients in European emergency departments and associated outcomes during the Covid-19 pandemic - a secondary analysis of the cross sectional EGERS study.

Open original sourceFull brief

AI-summarized from the linked source. Review the original article before applying to practice.

Key takeaways

Practice implications

Limitations & cautions

Exact source links

More updates for this clinical area

IV pantoprazole did not improve vomiting or oral tolerance in pediatric gastroenteritis

Dexmedetomidine did not improve early pain outcomes versus fentanyl for craniotomy

Chief complaint alone did not capture risk in older emergency patients